ANTIARRHYTHMIC ACTIVITY, ELECTROCARDIOGRAPHIC EFFECTS AND PHARMACOKINETICS OF THE ENCAINIDE METABOLITES O-DESMETHYL ENCAINIDE AND 3-METHOXY-O-DESMETHYL ENCAINIDE IN MAN

被引:41
作者
BARBEY, JT
THOMPSON, KA
ECHT, DS
WOOSLEY, RL
RODEN, DM
机构
[1] VANDERBILT UNIV,MED CTR,SCH MED,DEPT PHARMACOL,DIV CLIN PHARMACOL,MED CTR N,A-3308,NASHVILLE,TN 37232
[2] VANDERBILT UNIV,MED CTR,SCH MED,DIV CARDIOL,NASHVILLE,TN 37232
关键词
D O I
10.1161/01.CIR.77.2.380
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:380 / 391
页数:12
相关论文
共 42 条
[1]   RESPONSE TO ENCAINIDE OF REFRACTORY VENTRICULAR-TACHYCARDIA - CLINICAL-APPLICATION OF ASSAYS FOR PARENT DRUG AND METABOLITES [J].
ANDERSON, JL ;
STEWART, JR ;
JOHNSON, TA ;
LUTZ, JR ;
PITT, B .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1982, 4 (05) :812-819
[2]  
BENNETT PB, 1986, CIRCULATION, V74, P20
[3]  
BLAIR IA, 1986, 3RD WORLD C CLIN PHA
[4]   ARRHYTHMOGENICITY OF ENCAINIDE - THE ROLE OF QT INTERVAL [J].
BREN, GB ;
VARGHESE, PJ ;
KATZ, RJ ;
ROSS, AM .
AMERICAN JOURNAL OF CARDIOLOGY, 1981, 47 (02) :498-498
[5]   ENCAINIDE AND ITS METABOLITES - COMPARATIVE EFFECTS IN MAN ON VENTRICULAR ARRHYTHMIA AND ELECTROCARDIOGRAPHIC INTERVALS [J].
CAREY, EL ;
DUFF, HJ ;
RODEN, DM ;
PRIMM, RK ;
WILKINSON, GR ;
WANG, T ;
OATES, JA ;
WOOSLEY, RL .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 73 (02) :539-547
[6]   COMPARATIVE-STUDY OF ENCAINIDE AND DISOPYRAMIDE IN CHRONIC VENTRICULAR ARRHYTHMIAS - A DOUBLE-BLIND PLACEBO-CONTROLLED CROSSOVER STUDY [J].
CARON, JF ;
LIBERSA, CC ;
KHER, AR ;
KACET, S ;
WANSZELBAUM, H ;
DUPUIS, BA ;
POIRIER, JM ;
LEKIEFFRE, JP .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1985, 5 (06) :1457-1463
[7]   ENCAINIDE FOR REFRACTORY VENTRICULAR TACHYARRHYTHMIA [J].
CHESNIE, B ;
PODRID, P ;
LOWN, B ;
RAEDER, E .
AMERICAN JOURNAL OF CARDIOLOGY, 1983, 52 (05) :495-500
[8]  
DAVY JM, 1986, J PHARMACOL EXP THER, V237, P907
[9]   DIFFERENTIAL-EFFECTS OF O-DEMETHYL ENCAINIDE ON INDUCED AND SPONTANEOUS ARRHYTHMIAS IN THE CONSCIOUS DOG [J].
DAWSON, AK ;
RODEN, DM ;
DUFF, HJ ;
WOOSLEY, RL ;
SMITH, RF .
AMERICAN JOURNAL OF CARDIOLOGY, 1984, 54 (06) :654-658
[10]   TREATMENT OF FREQUENT VENTRICULAR ARRHYTHMIA WITH ENCAINIDE - ASSESSMENT USING SERIAL AMBULATORY ELECTROCARDIOGRAMS, INTRACARDIAC ELECTROPHYSIOLOGIC STUDIES, TREADMILL EXERCISE TESTS, AND RADIONUCLIDE CINEANGIOGRAPHIC STUDIES [J].
DIBIANCO, R ;
FLETCHER, RD ;
COHEN, AI ;
GOTTDIENER, JS ;
SINGH, SN ;
KATZ, RJ ;
BATES, HR ;
SAUERBRUNN, B .
CIRCULATION, 1982, 65 (06) :1134-1147