FAS-MEDIATED CYTOTOXICITY - AN IMMUNOEFFECTOR OR IMMUNOREGULATORY PATHWAY IN T-CELL-MEDIATED IMMUNE-RESPONSES

被引:78
作者
LARSEN, CP [1 ]
ALEXANDER, DZ [1 ]
HENDRIX, R [1 ]
RITCHIE, SC [1 ]
PEARSON, TC [1 ]
机构
[1] EMORY UNIV,SCH MED,DEPT SURG,ATLANTA,GA 30322
关键词
D O I
10.1097/00007890-199508000-00002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Fas/Fas ligand interactions serve as a signaling pathway for apoptosis (1-3), an important regulatory mechanism in the development and function of the immune system (4-9). Recent evidence that Fas-dependent apoptosis is also an important mode of T cell cytotoxicity (10-13) suggested that Fas might play a critical role in the effector phase of T-dependent immune responses, such as allograft rejection. We observed that Fas transcripts are constitutively expressed in syngeneic and allogeneic murine cardiac transplants, while Fas ligand (Fast) is up-regulated only in rejecting allografts. Surprisingly, the absence of an intact Fas/FasL pathway did not alter the tempo of allograft rejection, even CD4-dependent rejection. These results indicate that Fas/FasL interactions are not essential mediators of T cell-induced allograft damage. Rather, as suggested in other studies, the Fas pathway may be principally involved in the regulation of clonal expansion and subsequent contraction of T cell populations during immune responses.
引用
收藏
页码:221 / 224
页数:4
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