NEUROPEPTIDES IN SKIN-DISEASE - INCREASED VIP IN ECZEMA AND PSORIASIS BUT NOT AXILLARY HYPERHIDROSIS

被引：88

作者：

ANAND, P

SPRINGALL, DR

BLANK, MA

SELLU, D

POLAK, JM

BLOOM, SR

机构：

[1] HAMMERSMITH HOSP,DEPT MED,DU CANE RD,LONDON W12 0HS,ENGLAND

[2] HAMMERSMITH HOSP,DEPT HISTOCHEM,LONDON W12 0HS,ENGLAND

[3] EALING GEN HOSP,DEPT SURG,MIDDLESEX,ENGLAND

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1991年 / 124卷 / 06期

关键词：

D O I：

10.1111/j.1365-2133.1991.tb04948.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The neuropeptides vasoactive intestinal polypeptide (VIP), substance P and somatostatin were studied in skin biopsies from patients with eczema, psoriasis and axillary hyperhidrosis. VIP concentrations were elevated in skin affected by eczema and psoriasis, whereas substance P and somatostatin levels did not differ from controls. There was a higher concentration of VIP, but not of substance P or somatostatin, in normal axillary skin when compared to adjacent trunk skin, with abundant VIP-containing fibres surrounding eccrine sweat glands. The VIP concentration was unchanged in skin affected by axillary hyperhidrosis. VIP may increase local blood flow in eczema and psoriasis, but does not appear to play a role in axillary hyperhidrosis.

引用

页码：547 / 549

页数：3

共 18 条

[1] TOPICAL CAPSAICIN PRETREATMENT INHIBITS AXON REFLEX VASODILATATION CAUSED BY SOMATOSTATIN AND VASOACTIVE INTESTINAL POLYPEPTIDE IN HUMAN-SKIN [J].