HEMORRHAGE INDUCES C-FOS IMMUNOREACTIVITY IN SPINALLY PROJECTING NEURONS OF CAT SUBRETROFACIAL NUCLEUS

被引：50

作者：

MCALLEN, RM

BADOER, E

SHAFTON, AD

OLDFIELD, BJ

MCKINLEY, MJ

机构：

[1] Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville

来源：

BRAIN RESEARCH | 1992年 / 575卷 / 02期

基金：

英国医学研究理事会;

关键词：

C-FOS; VENTROLATERAL MEDULLA; HEMORRHAGE; BLOOD PRESSURE; VASOMOTOR PATHWAY;

D O I：

10.1016/0006-8993(92)90099-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuronal expression of c-fos product in the cat rostral ventrolateral medulla was studied by immunohistochemistry. Spinally projecting neurons of the subretrofacial (SRF) nucleus were pre-labeled by retrograde transport of fluorescent latex microspheres from the lumbar cord. In 3 animals which were bled by approximately 25% blood volume from a carotid cannula, 48-62% of SRF-spinal neurons expressed c-fos immunoreactivity. In 2 control animals, the corresponding values were 2% and 4%. The data show that bulbospinal neurons of presumed vasomotor function express c-fos in response to hemorrhage.

引用

页码：329 / 332

页数：4

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[1] GROWTH-FACTORS AND MEMBRANE DEPOLARIZATION ACTIVATE DISTINCT PROGRAMS OF EARLY RESPONSE GENE-EXPRESSION - DISSOCIATION OF FOS AND JUN INDUCTION [J].