STRUCTURAL-ANALYSIS OF THE HOX-3.1 TRANSCRIPTION UNIT AND THE HOX-3.2-HOX-3.1 INTERGENIC REGION

被引：40

作者：

AWGULEWITSCH, A

BIEBERICH, C

BOGARAD, L

SHASHIKANT, C

RUDDLE, FH

机构：

[1] YALE UNIV,DEPT BIOL,NEW HAVEN,CT 06511

[2] YALE UNIV,DEPT HUMAN GENET,NEW HAVEN,CT 06511

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 16期

关键词：

cis-regulatory elements; CT repeats; homeobox genes; murine; transcription start sites;

D O I：

10.1073/pnas.87.16.6428

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mouse Hox gene family is a set of mammalian homeobox genes that may represent developmental control genes. Complete information about the primary structure of these genes is a prerequisite for a systematic analysis of the mechanisms that determine their complex tempero-spatial expression patterns. In this report we describe the complete sequence of the Hox-3.1 locus and provide evidence for several closely spaced transcriptional start sites. Sequence analysis of the 5' region of the Hox-3.1 gene extending to its nearest upstream neighbor, Hox-3.2, allowed us to identify sequences known to be capable of interactions with transcription factors. Several of these sequence motifs are similar to cis-regulatory elements found in the regulatory regions of other known developmentally regulated genes.

引用

页码：6428 / 6432

页数：5

共 49 条

[1] SPATIAL RESTRICTION IN EXPRESSION OF A MOUSE HOMOEO BOX LOCUS WITHIN THE CENTRAL-NERVOUS-SYSTEM [J].