The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrins

被引：96

作者：

Bailly, P

Tontti, E

Hermand, P

Cartron, JP

Gahmberg, CG

机构：

[1] HELSINKI UNIV, DEPT BIOSCI, DIV BIOCHEM, SF-00014 HELSINKI, FINLAND

[2] INST NATL TRANSFUS SANGUINE, INSERM U76, F-75015 PARIS, FRANCE

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1995年 / 25卷 / 12期

关键词：

ICAM; LW; adhesion; leukocyte;

D O I：

10.1002/eji.1830251217

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leukocyte adhesion involves the leukocyte-specific integrins CD11a/CD18, CD11b/CD18 and CD11c/CD18, which bind to intercellular adhesion molecules (ICAM). Three ICAM have been described, and are expressed on leukocytes and various other cells, but are absent from red cells. Here, we show that the red cell Landsteiner-Wiener (LW) blood group glycoprotein is an ICAM which binds to the leukocyte-specific integrins. This finding has important implications in red cell physiology.

引用

收藏

页码：3316 / 3320

页数：5

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