PROTEOLYSIS, PROTEASOMES AND ANTIGEN PRESENTATION

被引：561

作者：

GOLDBERG, AL

ROCK, KL

机构：

[1] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DANA FARBER CANC INST, BOSTON, MA 02115 USA

来源：

NATURE | 1992年 / 357卷 / 6377期

关键词：

D O I：

10.1038/357375a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that degrade cytosolic and nuclear proteins. These particles have been implicated in ATP-ubiquitin-dependent proteolysis and in the processing of intracellular antigens for cytolytic immune responses.

引用

页码：375 / 379

页数：5

共 90 条

[1]

AHN JY, 1991, J BIOL CHEM, V266, P15746

[2] T-CELL RECOGNITION OF LYSOZYME - THE BIOCHEMICAL BASIS OF PRESENTATION [J].