AUTORADIOGRAPHIC VISUALIZATION OF DOPAMINE D-2 RECEPTORS IN THE MONKEY BRAIN USING THE SELECTIVE BENZAMIDE DRUG [H-3] RACLOPRIDE

被引：76

作者：

KOHLER, C ^{[1
]}

RADESATER, AC ^{[1
]}

机构：

[1] ASTRA LAKEMEDEL AB, DEPT NEUROPHARMACOL, S-15185 SODERTALJE, SWEDEN

来源：

NEUROSCIENCE LETTERS | 1986年 / 66卷 / 01期

关键词：

D O I：

10.1016/0304-3940(86)90170-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using the novel substituted benzamide drug [3H]raclopride in combination with in vitro receptor autoradiography, the distribution of dopamine D-2 receptors was studied in the monkey brain. Highest densities of D-2 receptors are present in dopamine-rich areas and the distribution shows the following rank order: caudatus and putamen > nucleus accumbens > olfactory tubercle > substantia nigra (pars compacta) > insular cortex > piriform and entorhinal cortex > substantia nigra (pars reticulata). In all of these areas [3H]raclopride binding was blocked by dopamine (1 .mu.M) and by D-2 receptor antagonists such as (+)-butaclamol, eticlopride and raclopride, while the D-1 receptor antagonist SCH 23390 (1 .mu.M) reduced [3H] raclopride binding by 15-20% in some restricted parts of the caudatus and putamen exclusively.

引用

页码：85 / 90

页数：6

共 25 条

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