COMMON WEST AFRICAN HLA ANTIGENS ARE ASSOCIATED WITH PROTECTION FROM SEVERE MALARIA

被引：1242

作者：

HILL, AVS

ALLSOPP, CEM

KWIATKOWSKI, D

ANSTEY, NM

TWUMASI, P

ROWE, PA

BENNETT, S

BREWSTER, D

MCMICHAEL, AJ

GREENWOOD, BM

机构：

[1] MRC LABS, FAJARA, SENEGAMBIA

[2] UNIV LONDON LONDON SCH HYG & TROP MED, DEPT EPIDEMIOL & POPULAT SCI, LONDON WC1E 7HT, ENGLAND

[3] ROYAL VICTORIA HOSP, BANJUL, SENEGAMBIA

来源：

NATURE | 1991年 / 352卷 / 6336期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/352595a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A large case-control study of malaria in West African children shows that a human leucocyte class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB1*1302-DQB1*0501), common in West Africans but rare in other racial groups, are independently associated with protection from severe malaria. In this population they account for as great a reduction in disease incidence as the sickle-cell haemoglobin variant. These data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens.

引用

页码：595 / 600

页数：6

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