THE X-LINKED METHYLATED DNA-BINDING PROTEIN, MECP2, IS SUBJECT TO X-INACTIVATION IN THE MOUSE

被引：31

作者：

ADLER, DA

QUADERI, NA

BROWN, SDM

CHAPMAN, VM

MOORE, J

TATE, P

DISTECHE, CM

机构：

[1] UNIV WASHINGTON,DEPT PATHOL,SEATTLE,WA 98195

[2] ST MARYS HOSP,UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND

[3] ROSWELL PK CANC INST,DEPT BIOL MOLEC,BUFFALO,NY 14263

[4] UNIV EDINBURGH,INST CELL & MOLEC BIOL,EDINBURGH EH9 3JR,MIDLOTHIAN,SCOTLAND

来源：

MAMMALIAN GENOME | 1995年 / 6卷 / 08期

关键词：

D O I：

10.1007/BF00356163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA methylation at the promoter region of X-linked genes is associated with the maintenance of X inactivation in mammals. One of the methylated DNA binding proteins, MECP2 that binds to methylated bases in DNA is encoded by a gene (Mecp2) located on the mouse X Chromosome (Chr). To determine whether this gene was expressed from the inactive X Chr, and X-autosome translocation (T(X;16)16H) system in which expression from the Mecp2 allele on the inactive X Chr could be assayed was used. Results from these experiments indicate that Mecp2 is subject to X inactivation in mouse.

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收藏

页码：491 / 492

页数：2

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