A CONTIGUOUS LINKAGE MAP OF CHROMOSOME-13Q WITH 39 DISTINCT LOCI SEPARATED ON AVERAGE BY 5.1 CENTIMORGANS

被引：39

作者：

BOWCOCK, AM

FARRER, LA

HEBERT, JM

BALE, AE

CAVALLISFORZA, L

机构：

[1] STANFORD UNIV,DEPT GENET,STANFORD,CA 94305

[2] YALE UNIV,SCH MED,DEPT HUMAN GENET,NEW HAVEN,CT 06510

[3] BOSTON UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02118

[4] BOSTON UNIV,SCH MED,SCH PUBL HLTH,BOSTON,MA 02118

[5] HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02114

来源：

GENOMICS | 1991年 / 11卷 / 03期

关键词：

D O I：

10.1016/0888-7543(91)90058-M

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A fine-structure linkage map of chromosome 13q is presented. This map contains 39 continuously linked loci defined by genotypes generated from the CEPH family DNAs with 56 probe and enzyme combinations. An alpha-satellite probe for sequences on chromosome 13 was included, resulting in a complete map of 13q with 39 distinct loci. The map spans 1.715 M in males and 2.099 M in females and the mean genetic distance between adjacent loci is 5.1 cM. Although there was generally a several-fold excess of female recombination in the interstitial portion of 13q, an excess of recombination in males was observed at both ends of this chromosomal arm. This map should be useful for the localization of any additional marker, gene, or disease locus of interest on chromosome 13q. © 1991.

引用

页码：517 / 529

页数：13

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