THE UROKINASE UROKINASE-RECEPTOR SYSTEM AND CANCER - INVASION

被引：68

作者：

CONESE, M

BLASI, F

机构：

[1] IST SCI SAN RAFFAELE, DEPT BIOL & TECHNOL RES, I-20132 MILAN, ITALY

[2] UNIV MILAN, DEPT GENET & MICROBIAL BIOL, MILAN, ITALY

来源：

BAILLIERES CLINICAL HAEMATOLOGY | 1995年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0950-3536(05)80273-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

u-PA binds with high affinity to its specific GPI-anchored receptor on the cell surface. The binding has at least two important consequences: (1) it enhances the rate of plasminogen activation on the cell surface; and (2) it focuses the u-PA proteolytic activity at the leading front of migrating cells. Several recent findings suggest that surface-bound u-PA is essential for the invasive ability of tumour cells, even if a picture is emerging indicating a. © 1995 Baillière Tindall. All rights reserved.

引用

页码：365 / 389

页数：25

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