HYPOTHALAMIC CONCENTRATION AND RELEASE OF NEUROPEPTIDE-Y INTO MICRODIALYSATES IS REDUCED IN ANORECTIC TUMOR-BEARING RATS

被引：69

作者：

CHANCE, WT ^{[1
]}

BALASUBRAMANIAM, A ^{[1
]}

DAYAL, R ^{[1
]}

BROWN, J ^{[1
]}

FISCHER, JE ^{[1
]}

机构：

[1] UNIV CINCINNATI, MED CTR, DEPT SURG, CINCINNATI, OH 45267 USA

来源：

LIFE SCIENCES | 1994年 / 54卷 / 24期

关键词：

ANOREXIA; NEUROPEPTIDE Y; MICRODIALYSIS;

D O I：

10.1016/0024-3205(94)90144-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hypothalamic concentration of neuropeptide Y was decreased significantly in anorectic tumor-bearing rats, while NPY level was increased significantly in matched carcass weight control rats as compared with freely-feeding controls. In vivo microdialysis of the perifomical hypothalamic area of tumor-bearing rats prior to the development of anorexia revealed no alteration in NPY in dialysates. Following the development of anorexia, however, tumor-bearing rats exhibited significant reduction in NPY concentration in dialysates as compared with either matched carcass weight or freely-feeding control group. These results suggest that hypothalamic NPY concentration and release are decreased selectively in anorectic tumor-bearing rats. Since NPY also elicits less feeding in tumor-bearing rats, dysfunction of hypothalamic NPY feeding mechanisms may be of primary importance in cancer anorexia.

引用

页码：1869 / 1874

页数：6

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