SYNAPSE FORMATION OCCURS IN ASSOCIATION WITH THE INDUCTION OF LONG-TERM POTENTIATION IN 2-YEAR-OLD RAT HIPPOCAMPUS INVITRO

被引：51

作者：

CHANG, FLF

ISAACS, KR

GREENOUGH, WT

机构：

[1] UNIV ILLINOIS,BECKMAN INST,405 N MATHEWS,CHAMPAIGN,IL 61820

[2] UNIV ILLINOIS,DEPT PSYCHOL,CHAMPAIGN,IL 61820

[3] UNIV ILLINOIS,NEUROSCI PROGRAM,CHAMPAIGN,IL 61820

[4] UNIV ILLINOIS,DEPT CELL & STRUCT BIOL,CHAMPAIGN,IL 61820

来源：

NEUROBIOLOGY OF AGING | 1991年 / 12卷 / 05期

关键词：

PLASTICITY; SENESCENCE; LEARNING; SYNAPTIC EFFICACY; SYNAPTOGENESIS;

D O I：

10.1016/0197-4580(91)90082-U

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Following induction of long-term potentiation in subfield CA1 of the hippocampal slice from 26-month-old rats, shaft synapse numbers increased by 44% and sessile spine synapse (synapses on stubby, headless spines) by 72%, with the more common mushroom-shaped spine synapses statistically unaltered. These effects are smaller than in prior work with young adults, whereas population spike amplitude changes were comparable to young adults. Reasons for the discrepancy are unclear, but the results confirm continuing capacity for induction of LTP in aged rats and indicate that substantial synaptogenic capacity also persists, but may be impaired, at these ages.

引用

页码：517 / 522

页数：6

共 28 条

[1]

APPLEGATE MD, 1988, J NEUROSCI, V8, P1096

[2] LONG-TERM SENSITIZATION IN APLYSIA INCREASES THE NUMBER OF PRESYNAPTIC CONTACTS ONTO THE IDENTIFIED GILL MOTOR NEURON L7 [J].