IN-VITRO INHIBITORY EFFECTS OF COMBINATIONS OF ANTIINFLUENZA AGENTS

被引：34

作者：

MADREN, LK

SHIPMAN, C

HAYDEN, FG

机构：

[1] UNIV VIRGINIA,HLTH SCI CTR,DEPT PATHOL & MED,CHARLOTTESVILLE,VA 22908

[2] UNIV VIRGINIA,SCH MED,DEPT INTERNAL MED,CHARLOTTESVILLE,VA 22908

[3] UNIV VIRGINIA,SCH MED,DEPT PATHOL,CHARLOTTESVILLE,VA 22908

[4] UNIV MICHIGAN,SCH DENT,DEPT BIOL & MAT SCI,ANN ARBOR,MI 48109

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1995年 / 6卷 / 02期

关键词：

COMBINATION CHEMOTHERAPY; INFLUENZA; NEURAMINIDASE INHIBITOR; RIBAVIRIN; RIMANTADINE;

D O I：

10.1177/095632029500600205

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To assess the possible interactions among candidate anti-influenza agents, dual combinations of rimantadine, ribavirin, 2'-deoxy-2'-fluoroguanosine (S-FDG) and 4-guanidino-Neu5Ac2en (GG167) were tested against clinical isolates of influenza A H3N2 and H1N1 subtype viruses in MDCK cells by ELISA. Each of the dual combinations showed additive effects, except for the combination of 2-FDG and ribavirin which was synergistic against the influenza A (H1N1) virus. However, this combination also enhanced cytotoxicity, In this assay influenza agents with differing mechanisms of antiviral interaction interacted in an additive fashion with respect to inhibition of viral replication,

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页码：109 / 113

页数：5

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