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THE NEUROPROTECTIVE EFFECT OF A NITRIC-OXIDE INHIBITOR IN A RAT MODEL OF FOCAL CEREBRAL-ISCHEMIA

被引：239
作者：
BUISSON, A
PLOTKINE, M
BOULU, RG
机构：
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1992年 / 106卷 / 04期
关键词：
CEREBRAL FOCAL ISCHEMIA IN RATS; NITRIC OXIDE; NO SYNTHASE INHIBITOR;
D O I：
10.1111/j.1476-5381.1992.tb14410.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Recent data showed that glutamate toxicity in primary cortical cultures is mediated by nitric oxide. In order to investigate the effect of inhibition of NO synthase on focal cerebral ischaemia in rats, we studied the histological consequences of a middle cerebral artery (MCA) occlusion after post-operative treatment with N(G)-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase. We found a significant reduction of cortical ( - 43%) and striatal ( - 25%) necrotic volumes induced by MCA occlusion, indicating that NO synthesis plays an important role in the neurotoxic cascade leading to neuronal damage after focal cerebral ischaemia in rats.
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页码：766 / 767
页数：2
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