DECIPHERING THE MESSAGE IN PROTEIN SEQUENCES - TOLERANCE TO AMINO-ACID SUBSTITUTIONS

被引：447

作者：

BOWIE, JU ^{[1
]}

REIDHAAROLSON, JF ^{[1
]}

LIM, WA ^{[1
]}

SAUER, RT ^{[1
]}

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

SCIENCE | 1990年 / 247卷 / 4948期

关键词：

D O I：

10.1126/science.2315699

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.

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页码：1306 / 1310

页数：5

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