AUTOANTIBODIES TO CYTOKINES - FRIENDS OR FOES

被引：226

作者：

BENDTZEN, K

SVENSON, M

JONSSON, V

HIPPE, E

机构：

[1] UNIV COPENHAGEN,RIGSHOSP,DEPT INFECT DIS M,DK-2200 COPENHAGEN N,DENMARK

[2] UNIV COPENHAGEN,GENTOFTE HOSP,DEPT INTERNAL MED & HAEMATOL,DK-2900 HELLERUP,DENMARK

来源：

IMMUNOLOGY TODAY | 1990年 / 11卷 / 05期

关键词：

D O I：

10.1016/0167-5699(90)90068-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokines form a network of communication signals between cells of the immune system, and between the immune system and other organs. They interact with structurally complex and often dynamically expressed target cell receptors. The recent demonstration of autoantibodies to cytokines, even in sera of normal individuals, suggests further complexities in the way that nature regulates cytokine functions. Based mainly on evidence obtained by investigating autoantibodies to interleukin 1α (IL-1α), Klaus Bendtzen and colleagues discuss the possibility that naturally occuring antibodies may function as specific physiological carriers and regulators of cytokines. © 1990.

引用

页码：167 / 169

页数：3

共 32 条

[1] ASSOCIATION BETWEEN HLA-DR2 AND PRODUCTION OF TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-1 BY MONONUCLEAR-CELLS ACTIVATED BY LIPOPOLYSACCHARIDE [J].