APLYSIA CREB2 REPRESSES LONG-TERM FACILITATION - RELIEF OF REPRESSION CONVERTS TRANSIENT FACILITATION INTO LONG-TERM FUNCTIONAL AND STRUCTURAL-CHANGE

被引：466

作者：

BARTSCH, D ^{[1
]}

GHIRARDI, M ^{[1
]}

SKEHEL, PA ^{[1
]}

KARL, KA ^{[1
]}

HERDER, SP ^{[1
]}

CHEN, M ^{[1
]}

BAILEY, CH ^{[1
]}

KANDEL, ER ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,COLL PHYSICIANS & SURGEONS,CTR NEUROBIOL & BEHAV,NEW YORK,NY 10032

来源：

CELL | 1995年 / 83卷 / 06期

关键词：

D O I：

10.1016/0092-8674(95)90213-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB-1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT.

引用

页码：979 / 992

页数：14

共 64 条

[1] C/EBP IS AN IMMEDIATE-EARLY GENE REQUIRED FOR THE CONSOLIDATION OF LONG-TERM FACILITATION IN APLYSIA [J].

ALBERINI, CM ;

GHIRARDI, M ;

METZ, R ;

KANDEL, ER .

CELL, 1994, 76 (06) :1099-1114

[2]

[Anonymous], 1968, MIND MNEMONIST

[3]

Ausubel F, 2002, SHORT PROTOCOLS MOL

[4] SPATIALLY RESOLVED DYNAMICS OF CAMP AND PROTEIN KINASE-A SUBUNITS IN APLYSIA SENSORY NEURONS [J].

BACSKAI, BJ ;

HOCHNER, B ;

MAHAUTSMITH, M ;

ADAMS, SR ;

KAANG, BK ;

KANDEL, ER ;

TSIEN, RY .

SCIENCE, 1993, 260 (5105) :222-226

[5] INHIBITORS OF PROTEIN AND RNA-SYNTHESIS BLOCK STRUCTURAL-CHANGES THAT ACCOMPANY LONG-TERM HETEROSYNAPTIC PLASTICITY IN APLYSIA [J].

BAILEY, CH ;

MONTAROLO, P ;

CHEN, M ;

KANDEL, ER ;

SCHACHER, S .

NEURON, 1992, 9 (04) :749-758

[6] MORPHOLOGICAL BASIS OF LONG-TERM HABITUATION AND SENSITIZATION IN APLYSIA [J].

BAILEY, CH ;

CHEN, M .

SCIENCE, 1983, 220 (4592) :91-93

[7]

BAILEY CH, 1989, J NEUROSCI, V9, P1774

[8] ULTRASTRUCTURE OF THE SYNAPSES OF SENSORY NEURONS THAT MEDIATE THE GILL-WITHDRAWAL REFLEX IN APLYSIA [J].

BAILEY, CH ;

THOMPSON, EB ;

CASTELLUCCI, VF ;

KANDEL, ER .

JOURNAL OF NEUROCYTOLOGY, 1979, 8 (04) :415-444

[9] LONG-TERM-MEMORY IN APLYSIA MODULATES THE TOTAL NUMBER OF VARICOSITIES OF SINGLE IDENTIFIED SENSORY NEURONS [J].

BAILEY, CH ;

CHEN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (07) :2373-2377

[10] STRUCTURAL-CHANGES ACCOMPANYING MEMORY STORAGE [J].

BAILEY, CH ;

KANDEL, ER .

ANNUAL REVIEW OF PHYSIOLOGY, 1993, 55 :397-426

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