PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION FROM COMPLEMENTARY-DNA OF A HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST

被引：1094

作者：

EISENBERG, SP ^{[1
]}

EVANS, RJ ^{[1
]}

AREND, WP ^{[1
]}

VERDERBER, E ^{[1
]}

BREWER, MT ^{[1
]}

HANNUM, CH ^{[1
]}

THOMPSON, RC ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DIV RHEUMATOL,DENVER,CO 80262

来源：

NATURE | 1990年 / 343卷 / 6256期

关键词：

D O I：

10.1038/343341a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human monocytes induced with adherent IgG secrete an interleukin-1 receptor antagonist which could be important for the in vivo regulation of IL-1 activity. A complementary DNA for this molecule has been isolated from a human monocyte library. Analysis of monocyte RNA indicates that the gene is transcriptionally regulated. The sequence of the receptor antagonist indicates that it is structurally similar to IL-lp. Expression of the cDNA in Escherichia coli yields IL-1 receptor antagonist activity. © 1990 Nature Publishing Group.

引用

页码：341 / 346

页数：6

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