THE LPR AND GLD GENES IN SYSTEMIC AUTOIMMUNITY - LIFE AND DEATH IN THE FAS LANE

被引：187

作者：

COHEN, PL ^{[1
]}

EISENBERG, RA ^{[1
]}

机构：

[1] UNIV N CAROLINA,SCH MED,DEPT MICROBIOL IMMUNOL,CHAPEL HILL,NC 27599

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 11期

关键词：

D O I：

10.1016/0167-5699(92)90066-G

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The single gene lpr and gld models of spontaneous systemic autoimmunity have attracted much attention in recent years. Here, Philip Cohen and Robert Eisenberg describe the fascinating recent findings that the lpr and Fas phenotypes result from defects in the Fas gene and, perhaps, in the ligand for fas, respectively.

引用

页码：427 / 428

页数：2

共 15 条

[1] DIFFERENCES DEFINED BY BONE-MARROW TRANSPLANTATION SUGGEST THAT LPR AND GLD ARE MUTATIONS OF GENES ENCODING AN INTERACTING PAIR OF MOLECULES [J].

ALLEN, RD ;

MARSHALL, JD ;

ROTHS, JB ;

SIDMAN, CL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (05) :1367-1375

[2] LPR AND GLD - SINGLE GENE MODELS OF SYSTEMIC AUTOIMMUNITY AND LYMPHOPROLIFERATIVE DISEASE [J].

COHEN, PL ;

EISENBERG, RA .

ANNUAL REVIEW OF IMMUNOLOGY, 1991, 9 :243-269

[3] THE POLYPEPTIDE ENCODED BY THE CDNA FOR HUMAN CELL-SURFACE ANTIGEN FAS CAN MEDIATE APOPTOSIS [J].

ITOH, N ;

YONEHARA, S ;

ISHII, A ;

YONEHARA, M ;

MIZUSHIMA, S ;

SAMESHIMA, M ;

HASE, A ;

SETO, Y ;

NAGATA, S .

CELL, 1991, 66 (02) :233-243

[4] DELETION OF POTENTIALLY SELF-REACTIVE T-CELL RECEPTOR SPECIFICITIES IN L3T4-, LYT-2- T-CELLS OF LPR MICE [J].

KOTZIN, BL ;

BABCOCK, SK ;

HERRON, LR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (06) :2221-2229

[5]

OEHM A, 1992, J BIOL CHEM, V267, P10709

[6] DNA FRAGMENTATION AND CELL-DEATH IS SELECTIVELY TRIGGERED IN ACTIVATED HUMAN-LYMPHOCYTES BY FAS ANTIGEN ENGAGEMENT [J].

OWENSCHAUB, LB ;

YONEHARA, S ;

CRUMP, WL ;

GRIMM, EA .

CELLULAR IMMUNOLOGY, 1992, 140 (01) :197-205

[7]

PERKINS DL, 1990, J IMMUNOL, V145, P549

[8] DOWN-REGULATION OF T-CELL RECEPTORS ON SELF-REACTIVE T-CELLS AS A NOVEL MECHANISM FOR EXTRATHYMIC TOLERANCE INDUCTION [J].

SCHONRICH, G ;

KALINKE, U ;

MOMBURG, F ;

MALISSEN, M ;

SCHMITTVERHULST, AM ;

MALISSEN, B ;

HAMMERLING, GJ ;

ARNOLD, B .

CELL, 1991, 65 (02) :293-304

[9] TOLERANCE-RELATED V-BETA CLONAL DELETIONS IN NORMAL CD4-8-, TCR-ALPHA/BETA+ AND ABNORMAL LPR AND GLD CELL-POPULATIONS [J].

SINGER, PA ;

BALDERAS, RS ;

MCEVILLY, RJ ;

BOBARDT, M ;

THEOFILOPOULOS, AN .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (06) :1869-1877

[10] AN INTRINSIC B-CELL DEFECT IS REQUIRED FOR THE PRODUCTION OF AUTOANTIBODIES IN THE LPR MODEL OF MURINE SYSTEMIC AUTOIMMUNITY [J].

SOBEL, ES ;

KATAGIRI, T ;

KATAGIRI, K ;

MORRIS, SC ;

COHEN, PL ;

EISENBERG, RA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (06) :1441-1449

← 1 2 →