INTERLEUKIN-10 (CYTOKINE SYNTHESIS INHIBITORY FACTOR) ACTS IN THE CENTRAL-NERVOUS-SYSTEM OF RATS TO REDUCE SLEEP

被引：104

作者：

OPP, MR ^{[1
]}

SMITH, EM ^{[1
]}

HUGHES, TK ^{[1
]}

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT MICROBIOL & IMMUNOL,GALVESTON,TX 77555

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1995年 / 60卷 / 1-2期

关键词：

HUMAN IMMUNODEFICIENCY VIRUS; CHRONIC FATIGUE SYNDROME; VIRUS; INFECTION; BEHAVIOR; IMMUNITY;

D O I：

10.1016/0165-5728(95)00066-B

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-10 (IL-10), originally designated a cytokine synthesis inhibitory factor, inhibits the synthesis of the pro-inflammatory cytokines IL-1 and tumor necrosis factor by stimulated human and mouse monocytes/macrophages; these cytokines are involved in the regulation of sleep. To determine if IL-10 reduces spontaneous sleep, we injected murine recombinant IL-IO intracerebroventricularly into rats prior to light onset. Non-rapid eye movements sleep was reduced. The behavioral responses to IL-IO were abolished by heat-inactivation of this cytokine. We believe these to be the first observations of central nervous system actions for this cytokine. These results further support the hypothesis that cytokines are involved in the regulation of sleep, and suggest an additional mechanism whereby sleep may be altered in response to an activated immune system.

引用

页码：165 / 168

页数：4

共 16 条

[1]

Borish, Streib, Jones, Dysregulated cytokine production in chronic fatigue syndrome, Proceedings of the American Association for Chronic Fatigue Syndrome, 29, (1994)

[2]

Buchwald, Pascualy, Bombardier, Kith, Sleep disorders in patients with chronic fatigue, Clin. Infect. Dis., 18, pp. S68-S72, (1994)

[3]

Dinarello, Interleukin-1 and interleukin-1 antagonism, Blood, 77, pp. 1627-1652, (1991)

[4]

Fiorentino, Bond, Mosmann, Two types of mouse T helper cell, IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med., 170, pp. 2081-2095, (1989)

[5]

Fiorentino, Zlotnik, Mosmann, Howard, O'Garra, IL-10 inhibits cytokine production by activated macrophages, J. Immunol., 147, pp. 3815-3822, (1991)

[6]

Hughes, Cadet, Rady, Tyring, Chin, Smith, Evidence for the production and action of interleukin-10 in pituitary cells, Cell. Mol. Neurobiol., 14, pp. 59-69, (1994)

[7]

Kapas, Krueger, Tumor necrosis factor-beta induces sleep fever and anorexia, Am J Physiol, 263, pp. R703-R707, (1992)

[8]

Krueger, Dinarello, Chedid, Promotion of slow-wave sleep (SWS) by a purified interleukin-1 (IL-1) preparation, Fed. Proc., 42, (1983)

[9]

Krueger, Dinarello, Shoham, Davenne, Walter, Kubillus, Interferon alpha-2 enhances slow-wave sleep in rabbits, Int. J. Immunopharmacol., 9, pp. 23-30, (1987)

[10]

Krueger, Toth, Floyd, Fang, Kapas, Bredow, Obal, Sleep, microbes and cytokines, Neuroimmunomodulation, 1, pp. 100-109, (1994)

← 1 2 →