TOMOGRAPHIC (PQCT) AND BIOMECHANICAL EFFECTS OF HPTH(1-38) ON CHRONICALLY IMMOBILIZED OR OVERLOADED RAT FEMURS

被引：17

作者：

CAPOZZA, R

MA, YF

FERRETTI, JL

META, M

ALIPPI, R

ZANCHETTA, J

JEE, WSS

机构：

[1] UNIV NACL ROSARIO,CONICET,CEMFOC,CIUNR,ROSARIO,ARGENTINA

[2] UNIV BUENOS AIRES,FAC DENT,DEPT PHYSIOL,BUENOS AIRES,DF,ARGENTINA

[3] METAB RES FDN FIM,BUENOS AIRES,DF,ARGENTINA

[4] UNIV UTAH,DIV RADIOBIOL,SALT LAKE CITY,UT 84112

来源：

BONE | 1995年 / 17卷 / 04期

关键词：

D O I：

10.1016/8756-3282(95)00297-Q

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Six-month old rats chronically submitted to right hindlimb immobilization (IM) with mechanical overload (OL) of the left leg were treated 1 month later with 200 ug/kg/d of hPTH(1-38) for 15 or 75 days. Peripheral quantitative computed tomography (pQCT) scans and bending tests showed that hPTH increased cortical mass and volumetric BMD (vCtBMD) in both legs. However, elastic modulus of cortical bone and diaphyseal load-bearing capacity were improved only in OL bones. Improvement of diaphyseal strength was attributable to that of cortical bone quality, yet a stronger mechanostatic response of cortical modeling to bone material quality was also observed in treated OL bones. Data support hPTH(1-38) use for improving cortical bone mass and strength and point out a physical activity interaction with therapeutic results.

引用

页码：S233 / S239

页数：7

共 32 条

[1] TREATMENT OF OSTEOPOROSIS WITH PARATHYROID PEPTIDE (HPTH 1-34) AND ESTROGEN - INCREASE IN VOLUMETRIC DENSITY OF ILIAC CANCELLOUS BONE MAY DEPEND ON REDUCED TRABECULAR SPACING AS WELL AS INCREASED THICKNESS OF PACKETS OF NEWLY FORMED BONE [J].