CIRCULATING INTERCELLULAR-ADHESION MOLECULE-1 LEVELS AND NEUTROPHIL ADHESION IN STROKE

被引：46

作者：

CLARK, WM ^{[1
]}

COULL, BM ^{[1
]}

BRILEY, DP ^{[1
]}

MAINOLFI, E ^{[1
]}

ROTHLEIN, R ^{[1
]}

机构：

[1] BOEHRINGER INGELHEIM PHARMACEUT,DEPT IMMUNOL,RIDGEFIELD,CT

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1993年 / 44卷 / 01期

关键词：

INTERCELLULAR ADHESION MOLECULES; STROKE; LEUKOCYTES; CELL ADHESION;

D O I：

10.1016/0165-5728(93)90275-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To examine whether changes in leukocyte adhesion properties occur during stroke, we measured circulating serum intercellular adhesion molecule 1 (cICAM-1) levels and neutrophil adhesion in acute stroke, patients at high risk of stroke, and in matched controls. Levels of cICAM-1 were significantly lower in the stroke group (186.2 +/- 15.6 ng ml-1) compared to controls (257.7 +/- 24.8) and risks (257.7 +/- 16.5). Neutrophil adhesion was significantLy higher in the stroke group (23.6 +/- 4.3%; n = 14) compared to controls (9.7 +/- 2.3%; n = 12) and risks (12.7 +/- 2.5%; n = 13). These data suggest that changes in leukocyte adhesion dynamics are occurring in acute stroke.

引用

页码：123 / 126

页数：4

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