PROTON MAGNETIC-RESONANCE SPECTROSCOPY OF HUMAN BRAIN INVIVO IN THE EVALUATION OF MULTIPLE-SCLEROSIS - ASSESSMENT OF THE LOAD OF DISEASE

被引：256

作者：

ARNOLD, DL

MATTHEWS, PM

FRANCIS, G

ANTEL, J

机构：

[1] Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec

来源：

MAGNETIC RESONANCE IN MEDICINE | 1990年 / 14卷 / 01期

关键词：

D O I：

10.1002/mrm.1910140115

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Image localized, water‐suppressed proton magnetic resonance spectra were obtained from affected brain in patients with multiple sclerosis. In patients with moderate to severe chronic disease, spectra revealed a decreased ratio of N‐acetylaspartate to creatine resonance intensities. A normal ratio was obtained from a large recently symptomatic MRI plaque that resolved without sequelae. We propose that the observed metabolite changes can be useful as an index of irreversible CNS injury. © 1990 Academic Press, Inc. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：154 / 159

页数：6

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