C-ELEGANS LIN-45 RAF GENE PARTICIPATES IN LET-60 RAS-STIMULATED VULVAR DIFFERENTIATION

被引：219

作者：

HAN, M ^{[1
]}

GOLDEN, A ^{[1
]}

HAN, YM ^{[1
]}

STERNBERG, PW ^{[1
]}

机构：

[1] CALTECH,HOWARD HUGHES MED INST,DIV BIOL 15629,PASADENA,CA 91125

来源：

NATURE | 1993年 / 363卷 / 6425期

关键词：

D O I：

10.1038/363133a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Vulval differentiation in Caenorhabditis elegans is controlled by intercellular signalling mediated by a receptor tyrosine kinase and a ras gene product. The lin-45 gene encodes a homologue of the raf family of serine/threonine kinases and is necessary for vulval differentiation. The lin-45 raf gene product appears to act downstream of the ras protein in this pathway. A proto-oncogene-mediated signalling pathway may be a common feature of metazoan development.

引用

页码：133 / 140

页数：8

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