INHIBITION OF PROTEIN TYROSINE PHOSPHATASE-ACTIVITY BY DIAMIDE IS REVERSED BY EPIDERMAL GROWTH-FACTOR IN FIBROBLASTS

被引：55

作者：

MONTEIRO, HP ^{[1
]}

IVASCHENKO, Y ^{[1
]}

FISCHER, R ^{[1
]}

STERN, A ^{[1
]}

机构：

[1] NYU MED CTR,DEPT PHARMACOL,550 1ST AVE,NEW YORK,NY 10016

来源：

FEBS LETTERS | 1991年 / 295卷 / 1-3期

关键词：

EGF RECEPTOR; PROTEIN TYROSINE PHOSPHATASE; OXIDATION REDUCTION;

D O I：

10.1016/0014-5793(91)81405-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diamide (azodicarboxylic acid bis(dimethylamide)) inhibits protein tyrosine phosphatase activity in fibroblasts without altering protein tyrosine kinase activity associated with the epidermal growth factor receptor. The loss of protein tyrosine phosphatase activity caused by diamide is reversed by 2-mercaptoethanol or epidermal growth factor.

引用

页码：146 / 148

页数：3

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