MODELS OF CARCINOGENESIS AS AN ESCAPE FROM MITOTIC INHIBITORS

被引：50

作者：

BELL, GI ^{[1
]}

机构：

[1] LOS ALAMOS SCI LAB, LOS ALAMOS, NM 87544 USA

来源：

SCIENCE | 1976年 / 192卷 / 4239期

关键词：

D O I：

10.1126/science.130679

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Diffusible mitotic inhibitors are assumed to govern proliferation of normal cells. Cancer cells may escape regulation by failing to recognize or secrete inhibitors. In the latter case, probabilities and expected times for reaching a critical clone size are given. Patterns of proliferation will depend on whether the inhibitor concentration is locally or systemically determined.

引用

页码：569 / 572

页数：4

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