LIPOPOLYSACCHARIDE TREATMENT IN-VIVO INDUCES TISSUE EXPRESSION OF GTP CYCLOHYDROLASE-I MESSENGER-RNA

被引：32

作者：

HATTORI, Y ^{[1
]}

OKA, M ^{[1
]}

KASAI, K ^{[1
]}

NAKANISHI, N ^{[1
]}

SHIMODA, SI ^{[1
]}

机构：

[1] MEIKAI UNIV,SCH DENT,DEPT BIOCHEM,SAKADO,SAITAMA 35002,JAPAN

来源：

FEBS LETTERS | 1995年 / 368卷 / 02期

关键词：

GTP CYCLOHYDROLASE I; MESSENGER-RNA; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE;

D O I：

10.1016/0014-5793(95)00689-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A significant induction of GTP cyclohydrolase I (GTPCH) mRNA was observed in lung, heart and kidney of rats treated with Lipopolysaccharide (LPS; 10 mg/kg i.v.). GTPCH mRNA levels in liver were high even in untreated rats, and remained elevated after LPS treatment. Parallel induction of nitric oxide synthase (NOS) mRNA was observed in these tissues of LPS-treated rats. Our results demonstrate induction of GTPCH mRNA after LPS treatment in vivo and provide molecular evidence for the increased GTPCH activity which may up-regulate NOS activity in vivo.

引用

页码：336 / 338

页数：3

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