THE 70-KDA S6-KINASE - REGULATION OF A KINASE WITH MULTIPLE ROLES IN MITOGENIC SIGNALING

被引：240

作者：

CHOU, MM

BLENIS, J

机构：

[1] Harvard Medical School, Boston

来源：

CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 06期

关键词：

D O I：

10.1016/0955-0674(95)80064-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The activation of the 70kDa S6 kinase, pp70(S6k), is a well documented mitogenic response, yet until recently little was known of how pp70(S6k) is activated, or of the identities of its crucial targets. The past year has revealed the complexity of pp70(S6k) regulation, with the overriding theme being that enzymes which have proven or putative roles in phospholipid metabolism mediate its activation. Studies also indicate that pp70(S6k) may regulate many more pathways than previously recognized.

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页码：806 / 814

页数：9

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