PRECLINICAL PHARMACOLOGY OF ROPINIROLE (SK-AND-F-101468-A) A NOVEL DOPAMINE-D2 AGONIST

被引:138
作者
EDEN, RJ [1 ]
COSTALL, B [1 ]
DOMENEY, AM [1 ]
GERRARD, PA [1 ]
HARVEY, CA [1 ]
KELLY, ME [1 ]
NAYLOR, RJ [1 ]
OWEN, DAA [1 ]
WRIGHT, A [1 ]
机构
[1] UNIV BRADFORD,NEUROPHARMACOL RES GRP,BRADFORD BD7 1DP,W YORKSHIRE,ENGLAND
关键词
DOPAMINE; D2; AGONIST; CENTRAL NERVOUS SYSTEM; RODENTS; MPTP; MARMOSETS; PARKINSONS DISEASE;
D O I
10.1016/0091-3057(91)90603-Y
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
These studies characterise the pharmacology of ropinirole, a selective D-2 agonist. High-affinity human caudate binding revealed a K(i) for D2 receptors of 2.9 x 10(-8) M with no affinity for D1 at 10(-4) M in the rat. Ropinirole was weakly active at alpha-2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha-1 and beta-adrenoceptors. In rodents, ropinirole, like apomorphine, caused biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice with no tolerance to the latter after 14 days treatment. Amphetamine caused ipsilateral responses in the lesioned mice. Ropinirole did not cause marked stereotypies. In marmosets ropinirole (0.05-1.0 mg/kg SC or 0.1 mg/kg PO) reversed all motor and behavioural deficits induced by MPTP. This response started 10-20 minutes after dosing, and exceeded 2 hours. No tolerance was seen following chronic b.i.d. treatment. Similar results were obtained with I-dopa plus benserazide; however, I-dopa always caused emesis, whereas beneficial effects were shown with ropinirole in the absence of this side effect. These results support the continued clinical assessment of ropinirole for the treatment of Parkinson's disease.
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页码:147 / 154
页数:8
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