ISOMERIZATION OF PROSTAGLANDIN H-2 INTO PROSTAGLANDIN D2 IN PRESENCE OF SERUM-ALBUMIN

被引：137

作者：

HAMBERG, M

FREDHOLM, BB

机构：

[1] KAROLINSKA INST, DEPT CHEM, S-10401 STOCKHOLM, SWEDEN

[2] KAROLINSKA INST, DEPT PHARMACOL, S-10401 STOCKHOLM, SWEDEN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1976年 / 431卷 / 01期

关键词：

D O I：

10.1016/0005-2760(76)90273-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The prostaglandin [PG] endoperoxide, PGH2, decomposes in aqueous media mainly into PGE2. In the presence of serum albumin from a number of species [bovine, guinea pig, rat, rabbit, human] PGH2 decomposes mainly into PGD2, an isomer of PGE2. The effect on endoperoxide decomposition exerted by serum albumin may have physiological significance since intact endoperoxides can be released from tissues and since the biological properties of PGE2 and D2 are quite different.

引用

收藏

页码：189 / 193

页数：5

相关论文

共 13 条

[1] PROSTAGLANDIN ENDOPEROXIDES .4. EFFECTS ON SMOOTH-MUSCLE [J].

HAMBERG, M ;

HEDQVIST, P ;

STRANDBERG, K ;

SVENSSON, J ;

SAMUELSSON, B .

LIFE SCIENCES, 1975, 16 (03) :451-462

[2] DETECTION AND ISOLATION OF AN ENDOPEROXIDE INTERMEDIATE IN PROSTAGLANDIN BIOSYNTHESIS [J].

HAMBERG, M ;

SAMUELSS.B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) :899-903

[3] ISOLATION AND STRUCTURE OF 2 PROSTAGLANDIN ENDOPEROXIDES THAT CAUSE PLATELET-AGGREGATION [J].

HAMBERG, M ;

SVENSSON, J ;

WAKABAYASHI, T ;

SAMUELSSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (02) :345-349

[4] PROSTAGLANDIN ENDOPEROXIDES - NOVEL TRANSFORMATIONS OF ARACHIDONIC-ACID IN HUMAN PLATELETS [J].

HAMBERG, M ;

SAMUELSS.B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (09) :3400-3404

[5] PROSTAGLANDIN ENDOPEROXIDES - NEW CONCEPT CONCERNING MODE OF ACTION AND RELEASE OF PROSTAGLANDINS .6. [J].

HAMBERG, M ;

SVENSSON, J ;

SAMUELSSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (10) :3824-3828

[6] PROSTAGLANDIN-D2 AS A POTENTIAL ANTITHROMBOTIC AGENT [J].

NISHIZAWA, EE ;

MILLER, WL ;

GORMAN, RR ;

BUNDY, GL ;

SVENSSON, J ;

HAMBERG, M .

PROSTAGLANDINS, 1975, 9 (01) :109-121

[7] ISOLATION AND PROPERTIES OF INTERMEDIATES IN PROSTAGLANDIN BIOSYNTHESIS [J].

NUGTEREN, DH ;

HAZELHOF, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 326 (03) :448-461

[8] EFFECT OF PROSTAGLANDIN E2 AND ASPIRIN ON SECONDARY AGGREGATION OF HUMAN PLATELETS [J].

SHIO, H ;

RAMWELL, P .

NATURE-NEW BIOLOGY, 1972, 236 (63) :45-&

[9]

SMITH JB, 1974, THROMB RES, V5, P291

[10]

SPECTOR AA, 1975, J LIPID RES, V16, P165