PREVENTION OF PROGRAMMED CELL-DEATH IN CAENORHABDITIS-ELEGANS BY HUMAN BCL-2

被引：513

作者：

VAUX, DL

WEISSMAN, IL

KIM, SK

机构：

[1] Department of Developmental Biology, Stanford Universily Medical Center, Stanford

来源：

SCIENCE | 1992年 / 258卷 / 5090期

关键词：

D O I：

10.1126/science.1470921

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Programmed cell death is a physiological process that eliminates unwanted cells. The bcl-2 gene regulates programmed cell death in mammalian cells, but the way it functions is not known. Expression of the human bcl-2 gene in the nematode Caenorhabditis elegans reduced the number of programmed cell deaths, suggesting that the mechanism of programmed cell death controlled by bcl-2 in humans is the same as that in nematodes.

引用

收藏

页码：1955 / 1957

页数：3

相关论文

共 27 条

[1] FORMATION OF THE 1ST CLEAVAGE SPINDLE IN NEMATODE EMBRYOS [J].

ALBERTSON, DG .

DEVELOPMENTAL BIOLOGY, 1984, 101 (01) :61-72

[2] CLONING THE CHROMOSOMAL BREAKPOINT OF T(14-18) HUMAN LYMPHOMAS - CLUSTERING AROUND JH ON CHROMOSOME-14 AND NEAR A TRANSCRIPTIONAL UNIT ON 18 [J].

BAKHSHI, A ;

JENSEN, JP ;

GOLDMAN, P ;

WRIGHT, JJ ;

MCBRIDE, OW ;

EPSTEIN, AL ;

KORSMEYER, SJ .

CELL, 1985, 41 (03) :899-906

[3] CLONING AND STRUCTURAL-ANALYSIS OF CDNAS FOR BCL-2 AND A HYBRID BCL-2/IMMUNOGLOBULIN TRANSCRIPT RESULTING FROM THE T(14-18) TRANSLOCATION [J].

CLEARY, ML ;

SMITH, SD ;

SKLAR, J .

CELL, 1986, 47 (01) :19-28

[4] NUCLEOTIDE-SEQUENCE OF A T(14,18) CHROMOSOMAL BREAKPOINT IN FOLLICULAR LYMPHOMA AND DEMONSTRATION OF A BREAKPOINT-CLUSTER REGION NEAR A TRANSCRIPTIONALLY ACTIVE LOCUS ON CHROMOSOME-18 [J].

CLEARY, ML ;

SKLAR, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (21) :7439-7443

[5] MECHANISMS AND FUNCTIONS OF CELL-DEATH [J].

ELLIS, RE ;

YUAN, JY ;

HORVITZ, HR .

ANNUAL REVIEW OF CELL BIOLOGY, 1991, 7 :663-698

[6]

FAUX DL, 1992, INT IMMUNOL, V4, P821

[7] A MODULAR SET OF LACZ FUSION VECTORS FOR STUDYING GENE-EXPRESSION IN CAENORHABDITIS-ELEGANS [J].

FIRE, A ;

HARRISON, SW ;

DIXON, D .

GENE, 1990, 93 (02) :189-198

[8] PREVENTION OF PROGRAMMED CELL-DEATH OF SYMPATHETIC NEURONS BY THE BCL-2 PROTOONCOGENE [J].

GARCIA, I ;

MARTINOU, I ;

TSUJIMOTO, Y ;

MARTINOU, JC .

SCIENCE, 1992, 258 (5080) :302-304

[9]

GOLDSTEIN P, 1991, IMMUNOL REV, V121, P29

[10] PROLIFERATION, DIFFERENTIATION AND DEGENERATION IN THE SPINAL GANGLIA OF THE CHICK EMBRYO UNDER NORMAL AND EXPERIMENTAL CONDITIONS [J].

HAMBURGER, V ;

LEVIMONTALCINI, R .

JOURNAL OF EXPERIMENTAL ZOOLOGY, 1949, 111 (03) :457-501