HLA-DP-BETA AND SUSCEPTIBILITY TO MULTIPLE-SCLEROSIS - AN ANALYSIS OF CAUCASOID AND JAPANESE PATIENT POPULATIONS

被引：59

作者：

BEGOVICH, AB

HELMUTH, RC

OKSENBERG, JR

SAKAI, K

TABIRA, T

SASAZUKI, T

STEINMAN, L

ERLICH, HA

机构：

[1] CETUS CORP,DEPT HUMAN GENET,DEPT DIAGNOST RES,EMERYVILLE,CA 94608

[2] STANFORD UNIV,DEPT NEUROL & GENET,STANFORD,CA 94305

[3] KYUSHU UNIV,MED INST BIOREGULAT,DEPT GENET,FUKUOKA 812,JAPAN

[4] NATL CTR NEUROL & PSYCHIAT,NATL INST NEUROSCI,DIV DEMYELINATING DIS & AGING,TOKYO,JAPAN

来源：

HUMAN IMMUNOLOGY | 1990年 / 28卷 / 04期

关键词：

D O I：

10.1016/0198-8859(90)90031-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nonradioactive sequence-specific oligonucleotide (SSO) probes specific for the HLA-DPβ locus have been used in a simple dot-blot assay to DPβ-type samples amplified by the polymerase chain reaction (pcr) from Caucasoid (n = 24) and Japanese (n = 23) patients with multiple sclerosis (ms) as well as ethnically matched controls. In contrast to previous reports, no DPβ allele was found to be increased in either patient population. However, the results do show a dramatic difference in the allele frequencies between the two control populations, further emphasizing the need for ethnically matched controls in studies of HLA and disease. © 1990.

引用

页码：365 / 372

页数：8

共 34 条

[1] HLA-DP TYPING BY DNA AMPLIFICATION AND HYBRIDIZATION WITH SPECIFIC OLIGONUCLEOTIDES [J].