A 2-TRIAL MEMORY TASK WITH AUTOMATED RECORDING - STUDY IN YOUNG AND AGED RATS

被引：330

作者：

DELLU, F ^{[1
]}

MAYO, W ^{[1
]}

CHERKAOUI, J ^{[1
]}

LEMOAL, M ^{[1
]}

SIMON, H ^{[1
]}

机构：

[1] UNIV BORDEAUX 2, PSYCHOBIOL COMPORTEMENT ADAPTAT LAB,INSERM,U259, RUE CAMILLE ST SAENS, F-33077 BORDEAUX, FRANCE

来源：

BRAIN RESEARCH | 1992年 / 588卷 / 01期

关键词：

Y-MAZE; PLACE EXPLORATION; OBJECT EXPLORATION; MEMORY RECOGNITION; AGING; RAT;

D O I：

10.1016/0006-8993(92)91352-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A two-trial recognition task, based on place or object exploration in a Y-maze, was developed to study memory in adult and aged rats. This paradigm avoids the use of electric shocks or deprivation that may have non-specific influences on the responses, and the task does not require learning of a rule. A number of behavioral parameters in several animals could be recorded automatically. These behavioral parameters were found to be differently influenced both by the type of recognition (place vs. object) and by the inter-trial interval (recognition retention time). Impaired recognition was also detected in 18-months-old rats. This recognition task which combines simplicity, sensitivity and high specificity may thus be a useful adjunct to our current battery of memory tasks.

引用

页码：132 / 139

页数：8

共 18 条

[1]

Berlyne D. E., 1960, CONFLICT AROUSAL CUR, DOI DOI 10.1037/11164-000

[2] SPONTANEOUS-ALTERNATION BEHAVIOR [J].