Fate of antibody to interferon (IFN) in chronic hepatitis C patients treated with recombinant IFN alpha 2 and retreated with lymphoblastoid IFN alpha

被引：9

作者：

Antonelli, G

Giannelli, G

Currenti, M

Simeoni, E

Milella, M

Schiraldi, O

Dianzani, F

机构：

[1] UNIV ROMA LA SAPIENZA,INST VIROL,I-00185 ROME,ITALY

[2] UNIV PISA,DEPT BIOMED,I-56100 PISA,ITALY

[3] UNIV BARI,INST MED CLIN 2,BARI,ITALY

[4] UNIV BARI,INST INFECT DIS,BARI,ITALY

来源：

INTERNATIONAL HEPATOLOGY COMMUNICATIONS | 1995年 / 4卷 / 04期

关键词：

interferon alpha; antibodies to interferon; hepatitis C virus; chronic hepatitis C infection; resistance to interferon therapy; interferon therapy;

D O I：

10.1016/0928-4346(95)00251-0

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Eight chronic hepatitis C patients treated with recombinant interferon (rIFN) alpha 2 developed neutralising antibodies against it, and lost response to therapy. After 6 months of follow-up, the treatment was switched to lymphoblastoid IFN alpha and clinical response was restored. The presence of neutralising antibodies to IFN in the sera of these patients was examined during the follow up and during the retreatment with the natural IFN alpha preparation. The results showed that in most of the patients antibodies to IFN alpha 2 disappeared very rapidly during the follow-up period and did not rise again when the patients were retreated with a different commercial preparation of IFN alpha.

引用

页码：232 / 237

页数：6

共 17 条

[1] RELATIVE FREQUENCY OF NONNEUTRALIZING ANTIBODIES TO INTERFERON (IFN) IN HEPATITIS PATIENTS TREATED WITH DIFFERENT IFN-ALPHA PREPARATIONS [J].