A CONFORMATIONALLY RESTRAINED SERIES OF AT(1)-SELECTIVE ANGIOTENSIN-II ANTAGONISTS

被引：7

作者：

CARPINO, PA

SNEDDON, SF

JARDINE, PD

MAGNUSAYRITEY, GT

RAUCH, AL

BURKARD, MR

机构：

[1] PFIZER INC,CENT RES,DEPT COMP CHEM,GROTON,CT 06340

[2] PFIZER INC,CENT RES,DEPT METAB DIS,GROTON,CT 06340

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(01)81128-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The benzyl linker in the angiotensin II receptor antagonist L-158,809 that separates the imidazo[4,5-b]pyridine ring and the 2-tetrazolylphenyl group was replaced by a series of bicyclic rings. The optimal bicyclic ring was found to be a dihydroindanyl group. Modification of the imidazo[4,5-b]pyridine group resulted in the discovery of a rigid analog that was as potent as L-158,809.

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页码：93 / 98

页数：6

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