POTENT ORAL ANTICONVULSANT ACTION OF CPP AND CPPENE IN DBA/2 MICE

被引：43

作者：

CHAPMAN, AG

GRAHAM, J

MELDRUM, BS

机构：

[1] Department of Neurology, Institute of Psychiatry, London, SES 8AF, De Crespigny Park

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 178卷 / 01期

基金：

英国医学研究理事会;

关键词：

(DBA/2 mouse); Anticonvulsants; Epilepsy; NMDA receptor antagonists;

D O I：

10.1016/0014-2999(90)94798-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

CPP (3-(2-carboxypiperazine-4-yl)-1-phosphonate), and its unsaturated analogue, CPPene (3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid), have potent anticonvulsant activity against sound-induced clortic seizures in DBA/2 mice. Following i.p. adminstration the protection is maximal at 1-2 h, and the ED50, values (μ mol/kg) are: D(-)-CPPene, 1.54; D(-)-CPP, 2.75; D,L(±)-CPP, 4.36. Following oral administration the protection is maximal at 3-4 h and the ED50 (μ mol/kg) values are: D(-)-CPPene, 40,19: D(-)-CPP, 65.80; D,L(±)-CPP, 108.1. © 1990.

引用

页码：97 / 99

页数：3

共 10 条

[1]

AEBISCHER B, 1989, HELV CHIM ACTA, V72, P1

[2] ANTICONVULSANT ACTION AND BIOCHEMICAL EFFECTS IN DBA 2 MICE OF CPP (3-((+/-)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONATE), A NOVEL N-METHYL-D-ASPARTATE ANTAGONIST [J].