XANTHINE-OXIDASE IS INCREASED AND CONTRIBUTES TO PARAQUAT-INDUCED ACUTE LUNG INJURY

被引：17

作者：

WAINTRUB, ML ^{[1
]}

TERADA, LS ^{[1
]}

BEEHLER, CJ ^{[1
]}

ANDERSON, BO ^{[1
]}

LEFF, JA ^{[1
]}

REPINE, JE ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,WEBB WARING LUNG INST,DEPT MED,DENVER,CO 80262

来源：

JOURNAL OF APPLIED PHYSIOLOGY | 1990年 / 68卷 / 04期

关键词：

lung albumin uptake; oxygen radicals; vascular injury; xanthine dehydrogenase activity;

D O I：

10.1152/jappl.1990.68.4.1755

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.

引用

页码：1755 / 1757

页数：3

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