IDENTIFICATION OF A MISSENSE MUTATION IN THE FACTOR-VIII GENE OF A MILD HEMOPHILIAC

被引：84

作者：

GITSCHIER, J

WOOD, WI

SHUMAN, MA

LAWN, RM

机构：

[1] GENENTECH INC,S SAN FRANCISCO,CA 94080

[2] UNIV CALIF SAN FRANCISCO,CANC RES INST,HEMATOL SECT,SAN FRANCISCO,CA 94143

来源：

SCIENCE | 1986年 / 232卷 / 4756期

关键词：

D O I：

10.1126/science.3012775

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：1415 / 1416

页数：2

共 12 条

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[5] PROTEOLYTIC PROCESSING OF HUMAN FACTOR-VIII - CORRELATION OF SPECIFIC CLEAVAGES BY THROMBIN, FACTOR XA, AND ACTIVATED PROTEIN-C WITH ACTIVATION AND INACTIVATION OF FACTOR-VIII COAGULANT ACTIVITY [J].

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[7] DETECTION AND SEQUENCE OF MUTATIONS IN THE FACTOR-VIII GENE OF HEMOPHILIACS [J].

GITSCHIER, J ;

WOOD, WI ;

TUDDENHAM, EGD ;

SHUMAN, MA ;

GORALKA, TM ;

CHEN, EY ;

LAWN, RM .

NATURE, 1985, 315 (6018) :427-430

[8] CHARACTERIZATION OF THE HUMAN FACTOR-VIII GENE [J].

GITSCHIER, J ;

WOOD, WI ;

GORALKA, TM ;

WION, KL ;

CHEN, EY ;

EATON, DH ;

VEHAR, GA ;

CAPON, DJ ;

LAWN, RM .

NATURE, 1984, 312 (5992) :326-330

[9] MOLECULAR-CLONING OF A CDNA-ENCODING HUMAN ANTIHEMOPHILIC-FACTOR [J].

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KNOPF, JL ;

WOZNEY, JM ;

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HEWICK, RM .

NATURE, 1984, 312 (5992) :342-347

[10] STRUCTURE OF HUMAN FACTOR-VIII [J].

VEHAR, GA ;

KEYT, B ;

EATON, D ;

RODRIGUEZ, H ;

OBRIEN, DP ;

ROTBLAT, F ;

OPPERMANN, H ;

KECK, R ;

WOOD, WI ;

HARKINS, RN ;

TUDDENHAM, EGD ;

LAWN, RM ;

CAPON, DJ .

NATURE, 1984, 312 (5992) :337-342

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