ANNEXIN-V - THE KEY TO UNDERSTANDING ION SELECTIVITY AND VOLTAGE REGULATION

被引：105

作者：

DEMANGE, P

VOGES, D

BENZ, J

LIEMANN, S

GOTTIG, P

BERENDES, R

BURGER, A

HUBER, R

机构：

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 07期

关键词：

D O I：

10.1016/0968-0004(94)90002-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Annexin V is a Ca2+-dependent membrane-binding protein that forms voltage-dependent Ca2+ channels in phospholipid bilayers and is the first ion channel to be structurally and functionally characterized. Data outlined here indicate that key amino acid residues act as selectivity filters and voltage sensors, thereby regulating the permeability of the channel pore to ions.

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页码：272 / 276

页数：5

相关论文

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