学术探索
学术期刊
新闻热点
数据分析
智能评审

EFFECTS OF EPIDERMAL GROWTH-FACTOR AND BASIC FIBROBLAST GROWTH-FACTOR ON GENERATION OF LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF FIMBRIA-FORNIX-LESIONED RATS

被引：49
作者：
ABE, K
ISHIYAMA, J
SAITO, H
机构：
[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Tokyo
来源：
BRAIN RESEARCH | 1992年 / 593卷 / 02期
关键词：
EPIDERMAL GROWTH FACTOR; BASIC FIBROBLAST GROWTH FACTOR; LONG-TERM POTENTIATION; DENTATE GYRUS; FIMBRIA-FORNIX LESION;
D O I：
10.1016/0006-8993(92)91332-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on long-term potentiation (LTP) in the dentate gyrus in vivo were investigated in fimbria-fornix (FF)-lesioned rats. Transection of FF resulted in decreased frequency of LTP generation. Intracerebroventricular injection of EGF (50 ng) and bFGF (50 ng) significantly facilitated LTP generation in the FF-lesioned rats. These results suggest that EGF and bFGF can promote the hippocampal LTP impaired by loss of subcortical afferents.
引用
收藏
页码：335 / 338
页数：4
相关论文
共 28 条
[1]   HUMAN BASIC FIBROBLAST GROWTH-FACTOR ENHANCES NEURONAL SURVIVAL AND MODULATES SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPUS [J].
ABE, K ;
XIE, FJ ;
SAITO, H .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 183 (06) :2348-2348
[2]   EFFECTS OF RECOMBINANT HUMAN BASIC FIBROBLAST GROWTH-FACTOR AND ITS MODIFIED PROTEIN CS23 ON SURVIVAL OF PRIMARY CULTURED NEURONS FROM VARIOUS REGIONS OF FETAL-RAT BRAIN [J].
ABE, K ;
TAKAYANAGI, M ;
SAITO, H .
JAPANESE JOURNAL OF PHARMACOLOGY, 1990, 53 (02) :221-227
[3]   A COMPARISON OF NEUROTROPHIC EFFECTS OF EPIDERMAL GROWTH-FACTOR AND BASIC FIBROBLAST GROWTH-FACTOR IN PRIMARY CULTURED NEURONS FROM VARIOUS REGIONS OF FETAL-RAT BRAIN [J].
ABE, K ;
TAKAYANAGI, M ;
SAITO, H .
JAPANESE JOURNAL OF PHARMACOLOGY, 1990, 54 (01) :45-51
[4]   EPIDERMAL GROWTH-FACTOR SELECTIVELY ENHANCES NMDA RECEPTOR-MEDIATED INCREASE OF INTRACELLULAR CA2+ CONCENTRATION IN RAT HIPPOCAMPAL-NEURONS [J].
ABE, K ;
SAITO, H .
BRAIN RESEARCH, 1992, 587 (01) :102-108
[5]  
ABE K, 1991, BRAIN RES, V547, P171
[6]   ABSENCE OF LONG-TERM POTENTIATION IN THE SUBCORTICALLY DEAFFERENTED DENTATE GYRUS [J].
BUZSAKI, G ;
GAGE, FH .
BRAIN RESEARCH, 1989, 484 (1-2) :94-101
[7]   EPIDERMAL GROWTH-FACTOR [J].
CARPENTER, G ;
COHEN, S .
ANNUAL REVIEW OF BIOCHEMISTRY, 1979, 48 :193-216
[8]  
DAVIES P, 1976, LANCET, V2, P1403
[9]   EPIDERMAL GROWTH-FACTOR IMMUNOREACTIVE MATERIAL IN THE CENTRAL NERVOUS-SYSTEM - LOCATION AND DEVELOPMENT [J].
FALLON, JH ;
SEROOGY, KB ;
LOUGHLIN, SE ;
MORRISON, RS ;
BRADSHAW, RA ;
KNAUER, DJ ;
CUNNINGHAM, DD .
SCIENCE, 1984, 224 (4653) :1107-1109
[10]   FIBROBLAST GROWTH-FACTOR [J].
GOSPODAROWICZ, D ;
NEUFELD, G ;
SCHWEIGERER, L .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1986, 46 (03) :187-204
123