BRAIN MEMBRANE FLUIDITY AND LIPID-PEROXIDATION IN ALZHEIMERS-DISEASE

被引：89

作者：

HAJIMOHAMMADREZA, I

BRAMMER, M

机构：

[1] Department of Neuroscience, Institute of Psychiatry, London

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 2-3期

关键词：

Alzheimer's disease; Lipid peroxidation; Malondialdehyde; Membrane fluidity;

D O I：

10.1016/0304-3940(90)90226-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Membrane fluidity and lipid peroxidation in 4 brain areas from patients with Alzheimer's disease (AD) and matched controls were determined by measuring fluorescence anisotropy of the lipophilic probe 1,6-diphenyl-1,3,5-hexatriene (DPH) and by the thiobarbituric acid test respectively. Fluorescence anisotropy of DPH was not changed in any of the 4 areas in AD compared to controls. Basal levels of malodialdehyde (MDA; an intermediate in the lipid peroxidation process) were also not changed in different brain regions of AD and controls. However, stimulated MDA production determined by incubating tissue with FeSO4 plus H2O2 produced significantly higher MDA levels in AD brain than in controls. © 1990.

引用

页码：333 / 337

页数：5

共 17 条

[1]

BARANY M, 1985, LANCET, V1, P517

[2]

Buege J A, 1978, Methods Enzymol, V52, P302

[3] X-RAY-DIFFRACTION EVIDENCE FOR MYELIN DISORDER IN BRAIN FROM HUMANS WITH ALZHEIMERS-DISEASE [J].