SPECIFICITY OF ACTION OF 3 POSSIBLE ANTAGONISTS OF AMINO ACID-INDUCED NEURONAL EXCITATIONS

被引：22

作者：

MCLENNAN, H ^{[1
]}

WHEAL, HV ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA, DEPT PHYSIOL, VANCOUVER V6T 1W5, BRITISH COLUMBI, CANADA

来源：

NEUROPHARMACOLOGY | 1976年 / 15卷 / 11期

关键词：

D O I：

10.1016/0028-3908(76)90041-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The actions of 3 compounds, glutamic acid diethylester, 1-hydroxy-3-aminopyrrolidone-2 and L-5,6-dimethoxyaporphine (nuciferine) which have been claimed to be antagonists of excitatory amino acid and particularly of glutamate excitations of central neurons, were compared in rats. Suitable electrophoretic doses of glutamic acid diethylester antagonized the effects of glutamate and aspartate to a much greater extent than those of homocysteate or acetylcholine. 1-Hydroxy-3-aminopyrrolidone-2 distinguished between glutamate/aspartate and homocysteate but not acetylcholine. Nuciferine showed no selectivity amongst the amino acids. Large applications of any of the compounds would antagonize the effects of all of the excitatory agonists.

引用

页码：709 / 712

页数：4

共 17 条

[1]

BENARI Y, 1975, J PHYSIOL-LONDON, V251, pP25

[2] ANTAGONISM OF 5-HYDROXYTRYPTAMINE BY LSD-25 IN CENTRAL NERVOUS SYSTEM - A POSSIBLE NEURONAL BASIS FOR ACTIONS OF LSD-25 [J].

BOAKES, RJ ;

BRADLEY, PB ;

BRIGGS, I ;

DRAY, A .

BRITISH JOURNAL OF PHARMACOLOGY, 1970, 40 (02) :202-&

[3] ANTAGONISM OF NEURONAL EXCITATION BY 1-HYDROXY-3-AMINOPYRROLIDONE-2 [J].

CURTIS, DR ;

JOHNSTON, GA ;

GAME, CJA ;

MCCULLOCH, RM .

BRAIN RESEARCH, 1973, 49 (02) :467-470

[4] EXCITATION OF MAMMALIAN CENTRAL NEURONS BY ACIDIC AMINO-ACIDS [J].

CURTIS, DR ;

DUGGAN, AW ;

WATKINS, JC ;

TEBECIS, AK ;

FELIX, D ;

JOHNSTON, GA .

BRAIN RESEARCH, 1972, 41 (02) :283-+

[5] IS 1-HYDROXY-3-AMINOPYRROLIDONE-2 (HA-966) A SELECTIVE EXCITATORY AMINO-ACID ANTAGONIST [J].

DAVIES, J ;

WATKINS, JC .

NATURE-NEW BIOLOGY, 1972, 238 (80) :61-&

[6] ANTAGONISM OF SYNAPTIC AND AMINO-ACID INDUCED EXCITATION IN CUNEATE NUCLEUS OF CAT BY HA-966 [J].

DAVIES, J ;

WATKINS, JC .

NEUROPHARMACOLOGY, 1973, 12 (07) :637-640

[7] MICROELECTROPHORETIC STUDIES ON DEPRESSANT ACTION OF HA-966 ON CHEMICALLY AND SYNAPTICALLY EXCITED NEURONS IN CAT CEREBRAL-CORTEX AND CUNEATE NUCLEUS [J].

DAVIES, J ;

WATKINS, JC .

BRAIN RESEARCH, 1973, 59 (SEP14) :311-322

[8]

DUGGAN AW, 1974, EXP BRAIN RES, V19, P522

[9]

DUGGAN AW, 1973, ARCH INT PHARMACOD T, V204, P147

[10] ANTAGONISM OF GLUTAMATE-INDUCED AND SYNAPTIC EXCITATIONS OF THALAMIC NEURONES [J].

HALDEMAN, S ;

HUFFMAN, RD ;

MARSHALL, KC ;

MCLENNAN, H .

BRAIN RESEARCH, 1972, 39 (02) :419-&

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