THE INFLUENCE OF THE SPARTEINE DEBRISOQUIN PHENOTYPE ON THE DISPOSITION OF FLECAINIDE

被引:64
作者
MIKUS, G
GROSS, AS
BECKMANN, J
HERTRAMPF, R
GUNDERTREMY, U
EICHELBAUM, M
机构
[1] DR MARGARETE FISCHERBOSCH INST KLIN PHARMAKOL,AUERBACHSTR 112,D-7000 STUTTGART 50,FED REP GER
[2] BUNDESGESUNDHEITSAMT,INST ARZNEIMITTEL,D-1000 BERLIN 33,FED REP GER
关键词
D O I
10.1038/clpt.1989.73
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:562 / 567
页数:6
相关论文
共 24 条
[1]   PHARMACOKINETICS OF FLECAINIDE IN PATIENTS WITH MILD AND MODERATE RENAL-FAILURE COMPARED WITH PATIENTS WITH NORMAL RENAL-FUNCTION [J].
BRAUN, J ;
KOLLERT, JR ;
BECKER, JU .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 31 (06) :711-714
[2]   FLECAINIDE HALF-LIFE PROLONGATION IN 2 PATIENTS WITH CONGESTIVE HEART-FAILURE AND COMPLEX VENTRICULAR ARRHYTHMIAS [J].
CAVALLI, A ;
MAGGIONI, AP ;
MARCHI, S ;
VOLPI, A ;
LATINI, R .
CLINICAL PHARMACOKINETICS, 1988, 14 (03) :187-188
[3]   APPLICATION OF A BONDED-PHASE EXTRACTION COLUMN FOR RAPID SAMPLE PREPARATION OF FLECAINIDE FROM HUMAN-PLASMA FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS - FLUORESCENCE OR ULTRAVIOLET DETECTION [J].
CHANG, SF ;
MILLER, AM ;
FOX, JM ;
WELSCHER, TM .
THERAPEUTIC DRUG MONITORING, 1984, 6 (01) :105-111
[4]   METABOLISM OF FLECAINIDE [J].
CONARD, GJ ;
OBER, RE .
AMERICAN JOURNAL OF CARDIOLOGY, 1984, 53 (05) :B41-B51
[5]   INFLUENCE OF THE DEFECTIVE METABOLISM OF SPARTEINE ON ITS PHARMACOKINETICS [J].
EICHELBAUM, M ;
SPANNBRUCKER, N ;
DENGLER, HJ .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (03) :189-194
[6]   POLYMORPHIC OXIDATION OF SPARTEINE AND DEBRISOQUINE - RELATED PHARMACOGENETIC ENTITIES [J].
EICHELBAUM, M ;
BERTILSSON, L ;
SAWE, J ;
ZEKORN, C .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1982, 31 (02) :184-186
[7]   ORAL FLECAINIDE PHARMACOKINETICS IN PATIENTS WITH IMPAIRED RENAL-FUNCTION [J].
FORLAND, SC ;
BURGESS, E ;
BLAIR, AD ;
CUTLER, RE ;
KVAM, DC ;
WEEKS, CE ;
FOX, JM ;
CONARD, GJ .
JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 28 (03) :259-267
[8]   EXTRACARDIAC ADVERSE-EFFECTS OF FLECAINIDE [J].
GENTZKOW, GD ;
SULLIVAN, JY .
AMERICAN JOURNAL OF CARDIOLOGY, 1984, 53 (05) :B101-B105
[9]   CHARACTERIZATION OF THE COMMON GENETIC-DEFECT IN HUMANS DEFICIENT IN DEBRISOQUINE METABOLISM [J].
GONZALEZ, FJ ;
SKODA, RC ;
KIMURA, S ;
UMENO, M ;
ZANGER, UM ;
NEBERT, DW ;
GELBOIN, HV ;
HARDWICK, JP ;
MEYER, UA .
NATURE, 1988, 331 (6155) :442-446
[10]   FLECAINIDE - A PRELIMINARY REVIEW OF ITS PHARMACODYNAMIC PROPERTIES AND THERAPEUTIC EFFICACY [J].
HOLMES, B ;
HEEL, RC .
DRUGS, 1985, 29 (01) :1-33