THE EFFECT OF HYPOLIPEMIC AGENTS ON PEROXISOMAL BETA-OXIDATION AND MIXED-FUNCTION OXIDASE ACTIVITIES IN PRIMARY CULTURES OF RAT HEPATOCYTES - RELATIONSHIP BETWEEN INDUCTION OF PALMITOYL-COA OXIDATION AND LAURIC ACID HYDROXYLATION

被引：74

作者：

LAKE, BG ^{[1
]}

GRAY, TJB ^{[1
]}

RIJCKEN, WRP ^{[1
]}

BEAMAND, JA ^{[1
]}

GANGOLLI, SD ^{[1
]}

机构：

[1] AGR UNIV WAGENINGEN,DEPT TOXICOL,6703 BC WAGENINGEN,NETHERLANDS

来源：

XENOBIOTICA | 1984年 / 14卷 / 03期

关键词：

D O I：

10.3109/00498258409151411

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：269 / 276

页数：8

共 28 条

[1] METABOLISM OF DIETHYLHEXYL PHTHALATE BY RATS ISOLATION AND CHARACTERIZATION OF URINARY METABOLITES [J].

ALBRO, PW ;

THOMAS, R ;

FISHBEIN, L .

JOURNAL OF CHROMATOGRAPHY, 1973, 76 (02) :321-330

[2] CARNITINE ACYLTRANSFERASES IN RAT-LIVER PEROXISOMES [J].

BIEBER, LL ;

KRAHLING, JB ;

CLARKE, PRH ;

VALKNER, KJ ;

TOLBERT, NE .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1981, 211 (02) :599-604

[3] REVIEW OF THE HEPATIC RESPONSE TO HYPOLIPEMIC DRUGS IN RODENTS AND ASSESSMENT OF ITS TOXICOLOGICAL SIGNIFICANCE TO MAN [J].

COHEN, AJ ;

GRASSO, P .

FOOD AND COSMETICS TOXICOLOGY, 1981, 19 (05) :585-605

[4]

DENT J G, 1978, Drug Metabolism and Disposition, V6, P96

[5] A MULTIPLE COMPARISON PROCEDURE FOR COMPARING SEVERAL TREATMENTS WITH A CONTROL [J].

DUNNETT, CW .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1955, 50 (272) :1096-1121

[6] CYTOCHROME-P-450 INDUCTION BY CLOFIBRATE - PURIFICATION AND PROPERTIES OF A HEPATIC CYTOCHROME-P-450 RELATIVELY SPECIFIC FOR THE 12-HYDROXYLATION AND 11-HYDROXYLATION OF DODECANOIC ACID (LAURIC-ACID) [J].

GIBSON, GG ;

ORTON, TC ;

TAMBURINI, PP .

BIOCHEMICAL JOURNAL, 1982, 203 (01) :161-168

[7] PEROXISOME PROLIFERATION IN PRIMARY CULTURES OF RAT HEPATOCYTES [J].

GRAY, TJB ;

LAKE, BG ;

BEAMAND, JA ;

FOSTER, JR ;

GANGOLLI, SD .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1983, 67 (01) :15-25

[8] PEROXISOME PROLIFERATION IN CULTURED RAT HEPATOCYTES PRODUCED BY CLOFIBRATE AND PHTHALATE ESTER METABOLITES [J].

GRAY, TJB ;

BEAMAND, JA ;

LAKE, BG ;

FOSTER, JR ;

GANGOLLI, SD .

TOXICOLOGY LETTERS, 1982, 10 (2-3) :273-279

[9] DIFFERENTIAL INDUCTION OF CYTOSOLIC EPOXIDE HYDROLASE, MICROSOMAL EPOXIDE HYDROLASE, AND GLUTATHIONE S-TRANSFERASE ACTIVITIES [J].

HAMMOCK, BD ;

OTA, K .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1983, 71 (02) :254-265

[10]

HOLLOWAY BR, 1980, BRIT J PHARMACOL, V69, pP318

← 1 2 3 →