NITRIC-OXIDE AND OXYGEN RADICALS - A QUESTION OF BALANCE

被引：479

作者：

DARLEYUSMAR, V

WISEMAN, H

HALLIWELL, B

机构：

[1] UNIV LONDON KINGS COLL, DEPT NUTR & DIETET, LONDON W8 7AH, ENGLAND

[2] UNIV LONDON KINGS COLL, NEURODEGENERAT DIS RES CTR, LONDON SW3 6LX, ENGLAND

来源：

FEBS LETTERS | 1995年 / 369卷 / 2-3期

关键词：

NITRIC OXIDE; SUPEROXIDE; REACTIVE NITROGEN SPECIES; PEROXYNITRITE; OXYGEN RADICALS;

D O I：

10.1016/0014-5793(95)00764-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The production of superoxide and nitric oxide individually has been associated with the development of several diseases but only recently has it been realised that interactions between them may also be important in disease pathology. The central hypothesis which is emerging is that the balance between nitric oxide and superoxide generation is a critical determinant in the aetiology of many human diseases including atherosclerosis, neurodegenerative disease, ischaemia-reperfusion and cancer. These ideas are discussed in this short overview and placed in the context of the current and future status of therapies which could modulate the balance between nitric oxide and superoxide.

引用

页码：131 / 135

页数：5

共 54 条

[1] VASCULAR BOUND RECOMBINANT EXTRACELLULAR SUPEROXIDE-DISMUTASE TYPE-C PROTECTS AGAINST THE DETRIMENTAL EFFECTS OF SUPEROXIDE RADICALS ON ENDOTHELIUM-DEPENDENT ARTERIAL RELAXATION [J].