PERSISTENT HIGH LACTATE LEVEL AS A SENSITIVE MR SPECTROSCOPY INDICATOR OF COMPLETED INFARCTION

被引：30

作者：

HOUKIN, K

KWEE, IL

NAKADA, T

机构：

[1] VET ADM MED CTR,NEUROCHEM RES LAB,MARTINEZ,CA 94553

[2] UNIV CALIF DAVIS,DEPT NEUROL,DAVIS,CA 95616

来源：

JOURNAL OF NEUROSURGERY | 1990年 / 72卷 / 05期

关键词：

cerebral infarction; lactate; magnetic resonance spectroscopy; rat;

D O I：

10.3171/jns.1990.72.5.0763

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Serial proton (1H) and phosphorus-31 (31P) magnetic resonance (MR) spectroscopy of cerebral infarction was performed in rats to assess the sensitivity of these techniques for use in clinical cerebral infarction. In this experimental chronic infarction model, 31P spectroscopy tended to return to a 'normal' pattern within 24 hours after induction of infarction in spite of pathologically proven completed infarction and, therefore, appeared not to be sensitive enough for clinical application. On the other hand, proton spectroscopy invariably showed persistent high lactate levels and was capable of distinguishing completed infarction from reperfused recovered brain. Persistent high lactate levels appear to be a good MR spectroscopic indicator of completed infarction.

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页码：763 / 766

页数：4

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