LINKAGE ANALYSIS IN NUCLEAR FAMILIES .2. RELATIONSHIP BETWEEN AFFECTED SIB-PAIR TESTS AND LOD SCORE ANALYSIS

被引：94

作者：

KNAPP, M

SEUCHTER, SA

BAUR, MP

机构：

[1] Institute for Medical Statistics, University of Bonn

来源：

HUMAN HEREDITY | 1994年 / 44卷 / 01期

关键词：

AFFECTED SIB-PAIR METHOD; MEAN TEST; PROPORTION TEST; LOD SCORE ANALYSIS; EQUIVALENT TESTS;

D O I：

10.1159/000154188

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It is believed that the main advantage of affected sib-pair tests is that their application requires no information about the underlying genetic mechanism of the disease. However, here it is proved that the mean test, which can be considered the most prominent of the affected sib-pair tests, is equivalent to lod score analysis for an assumed recessive mode of inheritance, irrespective of the true mode of the disease. Further relationships of certain sib-pair tests and lod score analysis under specific assumed genetic modes are investigated.

引用

页码：44 / 51

页数：8

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