COXSACKIEVIRUS B3 ADAPTED TO GROWTH IN RD CELLS BINDS TO DECAY-ACCELERATING FACTOR (CD55)

被引：168

作者：

BERGELSON, JM

MOHANTY, JG

CROWELL, RL

JOHN, NFS

LUBLIN, DM

FINBERG, RW

机构：

[1] HAHNEMANN UNIV,DEPT MICROBIOL & IMMUNOL,PHILADELPHIA,PA 19102

[2] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 03期

关键词：

D O I：

10.1128/JVI.69.3.1903-1906.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A coxsackievirus B3 (CB3) isolate adapted to growth in RD cells shows an alteration in cell tropism as a result of its capacity to bind a 70-kDa cell surface molecule expressed on these cells, We now show that this molecule is the complement regulatory protein, decay-accelerating factor (DAF) (CD55), Anti-DAF antibodies prevented CB3 attachment to the cell surface. Radiolabeled CB3 adapted to growth in RD cells bound to CHO cells transfected with human DAF, whereas CB3 (strain Nancy), the parental strain, did not bind to DAF transfectants. These results indicate that growth of CB3 in RD cells selected for a virus strain that uses DAF for cell surface attachment,

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页码：1903 / 1906

页数：4

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